PhD Student Biology – AML Therapy (m/f/d)

Job Description

wanted for 01.10.2025 at the Department of Medicine V, Hematology & Oncology, University Hospital Heidelberg.
For our project “Single cell multi-omics to unravel niche plasticity in AML therapy resistance“ we are looking for a PhD student. The project is part of the SFB/CRC 1709 “Cellular Plasticity in Myeloid Malignancies: From Mechanisms to Therapies”. In this CRC we aim to understand how plasticity i.e. non-genetic adaptations of the bone marrow niche induced by the disease or therapeutic agents contribute to drug resistance and relapse. Our ultimate goal is to develop new anti-leukemic therapies.
We are searching for a highly motivated and dedicated student with a strong background in molecular biology and/or cell biology and great enthusiasm for the bone marrow niche and therapy-resistance mechanisms. The PhD student will work in close collaboration with other CRC/SFB members and groups and will perform multiomics single cell sequencing analyses of mouse and human bone marrow cells at leukemia onset, throughout the course of treatment and upon relapse. Ideally, the candidate brings in strong expertise in cell culture and molecular biology techniques. The project also comprises a substantial amount of in vivo work, which will be performed in collaboration with experienced senior researchers. Therefore, a strong interest and motivation to support such experiments is required. The final aim of our studies is to translate the experimental findings into novel treatment strategies for AML patients.

Job-ID:V000014512

Field of application:Klinik für Hämatologie, Onkologie und Rheumatologie

Location:Heidelberg

Start date:01.10.2025

Job Category:Science and teaching

Working hours:Part time (65%)

Published:21.07.2025

Limitation:Temporary (2 Jahre, Weiterbeschäftigung angestrebt)

Contract:TV-L

Single cell multicomics of bone marrow cells: wet lab experiments involving preparation of cells for transplantation, isolation of cells, treatment with small molecule inhibitors
Computational analyses of scSeq data with support of experienced computational researchers
Literature research and manuscript writing
Imaging of mouse bone marrow
Analyses of clinical data and correlation with wet lab findings

Single cell multicomics of bone marrow cells: wet lab experiments involving preparation of cells for transplantation, isolation of cells, treatment with small molecule inhibitors
Computational analyses of scSeq data with support of experienced computational researchers
Literature research and manuscript writing
Imaging of mouse bone marrow
Analyses of clinical data and correlation with wet lab findings

Goal-oriented, individual training and development opportunities
Working with the latest techniques / technical equipment
Possibility of doctorate
Possibility to publish scientifically
Regular team meetings
Collectively agreed remuneration, attractive company pension scheme (VBL)
30 days vacation
Sustainable travel: job ticket
Family-friendly working environment: cooperative arrangements for childcare, subsidy for child vacation care, advice for employees with relatives in need of care
Wide range of health, prevention and sports offers